Blast pressure wave interaction with an elastic structure is investigated using a numerical analysis approach, which considers fluid-structure interaction (FSI) within an Arbitrary Lagrange Euler (ALE) framework. Approximate numerical procedures for solving the Riemann problem associated with the shock are implemented within the Godunov finite volume scheme for the fluid domain. The structural displacement predicted by ignoring FSI is larger than the corresponding displacement considering FSI. The influence of the structural and blast pressure wave parameters on the importance of FSI is studied using an analysis of variables. Two non-dimensional parameters corresponding to the ratios of blast duration to the time period of the structure and the velocity of the structure to the particle velocity of the incident blast pressure wave are identified. It is shown that for a given blast pressure wave, the error in the maximum displacement predicted by ignoring FSI effect during structural motion is directly proportional to the ratio of the structure velocity to the particle velocity of the incident blast pressure wave. There is a continuous exchange of energy between the structure and air during the structural motion, which is significant when the structural velocity is significant compared to the particle velocity of incident blast pressure wave. FSI effect become insignificant when the ratio of velocities starts approaching zero. © 2009 Elsevier Ltd. All rights reserved.