This paper demonstrates a facile methodology for fusing silver nanowires (AgNWs) at the nanoscale using a simple, cost-effective UV-ozone treatment. The fusing process not only resulted in interesting morphologies but also reduced the sheet resistance from 100 to 15 ω/sq. The process optimization ensued in the fusion of AgNWs at the edges with different bending angles that lie between 100 and 140°. The mechanism behind the fusing was elucidated primarily using high-resolution transmission electron microscopy analysis. The optimized process was replicated on top of a silk-poly(vinyl)alcohol (S-PVA) composite that is proven to be thermally stable, flexible, transparent, and biocompatible. This unique combination of fused AgNWs on top of S-PVA is a viable, cost-effective, and scalable prototype for flexible transparent conducting electrodes (FTCEs). A flexible biomemristor was fabricated using ZnO nanoparticles as an active layer and gold and AgNWs as top and bottom electrodes, respectively. The fabricated biomemristor on S-PVA exhibited oxygen vacancy-based RScharacteristics at a lower set/reset voltage of +0.25 V/-1 V with an excellent ROFF/RONratio of 3.5 × 103, higher switching endurance of 500 cycles, and stable data retention of greater than 104seconds. The strategy outlined here provides a simple, facile, and best optimized solution for the preparation of high-performance and biocompatible FTCEs for the next-generation wearable optoelectronic and biomedical devices. © 2022 American Chemical Society. All rights reserved.