The skin is the largest multifunctional organ, that is, protective, self-healing, and proficient of sensing. Being exposed, it is one of the undoubtly easily injured organs. To heal an injured skin, a variety of approaches are in existence by implementing various hydrogels, chemically modified polymers, and a number of cellular therapies. Researchers have already fabricated various artificial skins whose properties are alike to those of human skin that is accountable for various important physiological functions. The modern recent strategies embrace scaffolds to lead skin regeneration, 3D printing, bioreactors to assist mature skin tissue in vitro, and electronic skin to develop numerous sensory functions. This chapter abridge all the recent advances associated to skin tissue development. Additionally, some current fabrication technologies of artificial skin are discussed. In summary, the artificial skin with the current new approaches is an encouraging candidate to be first among other tissues to be appropriate for skin tissue engineering applications in severely injured patients. © 2022 Elsevier Inc. All rights reserved.