An efficient ring-closing metathesis reaction based approach to 1,2,2-trimethylcyclopentanemethanol. Formal synthesis of (±)-herbertene and (±)-cuparenes
A formal synthesis of the aromatic sesquiterpenes (±)-herbertene and (±)-cuparenes is accomplished via an efficient synthesis of 1,2,2-trimethylcyclopentanemethanol employing a combination of Claisen rearrangement and ring-closing metathesis reactions.