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An Approach to One-Pot Regioselective Synthesis of Indenones through Palladium-Catalyzed Annulation in Water
Published in Wiley-VCH Verlag
2018
Volume: 2018
   
Issue: 30
Pages: 4135 - 4146
Abstract
A one-pot synthesis of indenones is presented. The process involves palladium-catalyzed annulation of ortho-halobenzaldehydes with internal alkynes. Notably, it proceeded successfully in water as the sole, and green, solvent. Significantly, unlike in earlier reports, this protocol showed excellent regioselectivity with unsymmetrical alkylarylacetylenes. Further, the strategy was extended to a one-pot synthesis of a neolignan natural product. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetEuropean Journal of Organic Chemistry
PublisherData powered by TypesetWiley-VCH Verlag
ISSN1434193X