A titania based mixed oxide support, 90 wt % TiO2-Al2O3 (9OTi-Al) was synthesized by sol-gel method and characterized. The XRD pattern revealed no rutile peak even up to a calcination temperature of 1073 K. Several vanadium oxide catalysts supported on 9OTi-Al were synthesized by the incipient wetness impregnation method. The detailed characterization studies revealed presence of only molecularly dispersed surface vanadia species. Adsorption of alkane (ethane or propane) over supported vanadia catalysts showed various adsorbed species such as alkoxide, aldehyde/ketone, formate, acetate, and enolate species. The formation of alkoxide species suggested that the adsorption of alkane occurred through the abstraction of hydrogen. The carboxylated species formed from aldehyde/ketone or enolate species were the precursor for the formation of carboxides. The activity studies of xV9OTi-Al catalysts calcined at different temperature revealed that the variation in activity depends on calcinations temperature and vanadia loading. However, the activity was not related to the decrease in surface area and anatase to rutile phase transformation. Contact time studies and kinetic parameters estimated revealed that the activity and propylene yield depends on the vanadia loading. The kl/k2 ratio, which is an important parameter for tuning propylene yield, increased with an increase vanadium oxide loading. This is an abstract of a paper presented at the 8th World Congress of Chemical Engineering (Montréal, Quebec, Canada 8/23-27/2009).