Standard 12-lead (S12) system and Mason-Likar 12-lead (ML12) system despite of being most acceptable systems for clinical usage are not the preferred lead systems for remote monitoring (RM) applications. Usually RM applications involve wireless transmission of signals and a 2-3 lead system is preferred for bandwidth and storage limitations and data transmission time. Generally, ECG compression techniques are applied for the same, however, compression ratio (CR) depends on the number of channels and decreases with the increase in number of channels. Thus, it facilitates the usage of a 2-3 lead system. However, a reduced lead (RL) system with 2-3 leads may be inadequate for the information desired by the cardiologists who are accustomed to S12 or ML12 system pertaining to its decades old usage. In this paper, we attempt to provide solution to both technical and non-technical limitations of RM applications. We reconstruct S12 and ML12 systems from Reduced 3-lead (R3L) system comprising of basis leads I, II, V2 using personalized or patient-specific transformation. Two separate investigations have been carried out for S12 and ML12 with their corresponding R3L systems comprising of their respective basis leads. PhysioNet PTBDB and INCARTDB after wavelet based preprocessing were used in this investigation. R2 statistics, correlation (rx) and regression (bx) coefficients were used to evaluate reconstructed signal against the original signal and the mean values obtained were 96.53%, 0.982 and 0.968 (S12) and 96.53%, 0.982 and 0.968 (ML12) respectively. R3L system reduces number of leads and electrodes from 12 and 10 to 3 and 5 respectively, lowers bandwidth and storage requirements, data transmission time and increases CR. The study shows that basis leads obtained from S12 outperforms the basis leads of ML12 for reconstruction of precordial leads. © 2013 IEEE.