Herein, a 2-furyl-3-hydroxychromone-based deoxyuridine analogue was synthesized and incorporated into DNA. Its ESIPT mechanism, investigated by steady-state and time-resolved spectroscopy, was found to be highly sensitive to hydration through its ratiometric response. As a result, this analogue demonstrated a unique on-off dual emissive behavior which allows monitoring DNA hybridization as well as discriminating matched from mismatched duplexes, and B from A conformations. © 2016 The Royal Society of Chemistry.

Krishna Gavvala

Department of Chemistry

N.P.F. Barthes

D. Bonhomme

A.S. Dabert-Gay

D. Debayle

B.Y. Michel

A. Burger

Y. Mély

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RSC Advances

A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

Journal	Data powered by TypesetRSC Advances
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	20462069