An efficient one-pot sequential intermolecular aza-Michael addition and Pd-catalyzed intramolecular Buchwald-Hartwig α-arylation of secondary amines have been investigated, for the synthesis of tetrahydroisoquinolines. This method is simple and furnished products in very good yield and also successfully applied for the synthesis of novel aza-spirotricylcic ethers. © 2012 Elsevier Ltd. All rights reserved.

Satyanarayana Gedu

Department of Chemistry

A.G.K. Reddy

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IIT Hyderabad

Tetrahedron

A simple efficient sequential one-pot intermolecular aza-Michael addition and intramolecular Buchwald-Hartwig α-arylation of amines: Synthesis of functionalized tetrahydroisoquinolines

Journal	Tetrahedron
ISSN	00404020