In this paper, we present an application of the Cognitive Networking paradigm to the problem of dynamic channel selection in infrastructured wireless networks. We first discuss some of the key challenges associated with the cognitive control of wireless networks. Then we introduce our solution, in which a Neural Network-based cognitive engine learns how environmental measurements and the status of the network affect the performance experienced on different channels, and can therefore dynamically select the channel which is expected to yield the best performance for the mobile users. We carry out performance evaluation of the proposed system by experimental measurements on a testbed implementation; the obtained results show that the proposed cognitive engine is effective in achieving performance enhancements with respect to state-of-the-art channel selection strategies. ©2009 IEEE.