Isoflavans have gained considerable interest owing to their potential health benefits. Herein, we have presented a straightforward strategy for isoflavans synthesis. The strategy features an intermolecular [Cu]-catalyzed arylation of malonates and an intramolecular [Pd]-catalyzed Buchwald coupling of hydroxy tethered bromoarenes as the key transformations. This protocol enabled the synthesis of a variety of isoflavan analogs. © 2020 Wiley Periodicals LLC.