This work proposes an energy efficient wearable CMOS biomedical signal acquisition and digitization scheme powered by RF energy harvesting circuit. The system consists of a ultra-low power analog front end (AFE) incorporating low noise instrumentation amplifier (IA)(CMRR=75dB), two programmable gain amplifiers (PGA), mixed signal automatic gain control (AGC) and a successive approximation register (SAR) analog to digital converter (ADC)(10-bit). The full system is powered by a power aware RF energy harvesting circuit for an input range of -26dBm to -8dBm. The AFE along with ADC consumes 343nA with 1V supply voltage in UMC 0.18μm CMOS technology. © 2016 IEEE.